Clinical and Serologic Markers of Periodontal Infection and Chronic Kidney Disease. Commentary
Identifieur interne : 006552 ( Main/Exploration ); précédent : 006551; suivant : 006553Clinical and Serologic Markers of Periodontal Infection and Chronic Kidney Disease. Commentary
Auteurs : Frank A. Scannapieco [États-Unis] ; Mandip Panesar [États-Unis] ; Monica A. Fisher [États-Unis] ; George W. Taylor [États-Unis] ; Panos N. Papapanou [États-Unis] ; Mahboob Rahman [États-Unis] ; Sara M. Debanne [États-Unis]Source :
- Journal of periodontology [ 0022-3492 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Chronic kidney disease and its concomitant sequelae represent a major public health problem. Recent data suggest periodontal infection contributes to chronic kidney disease. Methods: This United States population-based study of 4,053 adults ≥40 years of age investigated the association between chronic kidney disease and clinical measures and serologic markers of periodontal infection. Chronic kidney disease was defined as moderate-to-severe reduction of kidney function with glomerular filtration rate of 15 to 59 ml/minute/1.73 m2 based on stages 3 and 4 of the Kidney Disease Outcome Quality Initiative. Chronic oral inflammatory burden was measured as 1) clinical periodontal infection categorized as no periodontal disease, periodontal disease (at least one tooth with ≥4 mm loss of attachment and bleeding on probing as an indicator of inflammation), or edentulism and 2) serum immunoglobulin G antibody response to Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) and Porphyromonas gingivalis. Multiple logistic regression modeling quantified the association between chronic kidney disease and chronic inflammatory burden and other risk factors. Results: Nine percent of the study population had chronic kidney disease, 22% had high A. actinomycetemcomitans antibody titer, 24% had high P. gingivalis antibody titer, 9% had periodontal disease, and 17% were edentulous. After simultaneously adjusting for recognized risk factors, adults with a high A. actinomycetemcomitans titer were less likely to have chronic kidney disease (adjusted odds ratio [ORAdj] = 0.67; 95% confidence interval [Cl]: 0.46 to 0.98), and adults with edentulism were more likely to have chronic kidney disease (ORAdj = 1.64; 95% CI: 1.11 to 2.44). Conclusion: These results support considering edentulism and low serum titer to A. actinomycetemcomitans as risk indicators for chronic kidney disease.
Affiliations:
- États-Unis
- Michigan, Ohio, État de New York
- Buffalo (New York), New York
- Université Columbia, Université d'État de New York à Buffalo
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Scannapieco</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Oral Biology, School of Dental Medicine, University at Buffalo</s1><s2>Buffalo, NY</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">Buffalo (New York)</settlement></placeName><orgName type="university">Université d'État de New York à Buffalo</orgName></affiliation></author><author><name sortKey="Panesar, Mandip" sort="Panesar, Mandip" uniqKey="Panesar M" first="Mandip" last="Panesar">Mandip Panesar</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, School of Medicine, Universityat Buffalo</s1><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Medicine, School of Medicine, Universityat Buffalo</wicri:noRegion></affiliation></author><author><name sortKey="Fisher, Monica A" sort="Fisher, Monica A" uniqKey="Fisher M" first="Monica A." last="Fisher">Monica A. Fisher</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Orthodontics, School of Dental Medicine, Case Western Reserve University</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Taylor, George W" sort="Taylor, George W" uniqKey="Taylor G" first="George W." last="Taylor">George W. Taylor</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan</s1><s2>Ann Arbor, MI</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. 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Commentary</title><author><name sortKey="Scannapieco, Frank A" sort="Scannapieco, Frank A" uniqKey="Scannapieco F" first="Frank A." last="Scannapieco">Frank A. Scannapieco</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Oral Biology, School of Dental Medicine, University at Buffalo</s1><s2>Buffalo, NY</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">Buffalo (New York)</settlement></placeName><orgName type="university">Université d'État de New York à Buffalo</orgName></affiliation></author><author><name sortKey="Panesar, Mandip" sort="Panesar, Mandip" uniqKey="Panesar M" first="Mandip" last="Panesar">Mandip Panesar</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, School of Medicine, Universityat Buffalo</s1><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Medicine, School of Medicine, Universityat Buffalo</wicri:noRegion></affiliation></author><author><name sortKey="Fisher, Monica A" sort="Fisher, Monica A" uniqKey="Fisher M" first="Monica A." last="Fisher">Monica A. Fisher</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Orthodontics, School of Dental Medicine, Case Western Reserve University</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Taylor, George W" sort="Taylor, George W" uniqKey="Taylor G" first="George W." last="Taylor">George W. Taylor</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan</s1><s2>Ann Arbor, MI</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Section of Oral and Diagnostic Sciences, Division of Periodontics, College of Dental Medicine, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Rahman, Mahboob" sort="Rahman, Mahboob" uniqKey="Rahman M" first="Mahboob" last="Rahman">Mahboob Rahman</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Nephrology and Hypertension, School of Medicine, Case Western Reserve University</s1><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Division of Nephrology and Hypertension, School of Medicine, Case Western Reserve University</wicri:noRegion></affiliation></author><author><name sortKey="Debanne, Sara M" sort="Debanne, Sara M" uniqKey="Debanne S" first="Sara M." last="Debanne">Sara M. Debanne</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University</s1><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of periodontology</title><title level="j" type="abbreviated">J. periodontol.</title><idno type="ISSN">0022-3492</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of periodontology</title><title level="j" type="abbreviated">J. periodontol.</title><idno type="ISSN">0022-3492</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term><term>Chronic kidney disease</term><term>Dentistry</term><term>Edentulousness</term><term>Infection</term><term>Jaw</term><term>Kidney disease</term><term>Periodontal disease</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Infection</term><term>Néphropathie chronique</term><term>Edentation</term><term>Anticorps</term><term>Mâchoire</term><term>Pathologie du rein</term><term>Parodontopathie</term><term>Facteur risque</term><term>Dentisterie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Chronic kidney disease and its concomitant sequelae represent a major public health problem. Recent data suggest periodontal infection contributes to chronic kidney disease. Methods: This United States population-based study of 4,053 adults ≥40 years of age investigated the association between chronic kidney disease and clinical measures and serologic markers of periodontal infection. Chronic kidney disease was defined as moderate-to-severe reduction of kidney function with glomerular filtration rate of 15 to 59 ml/minute/1.73 m<sup>2</sup> based on stages 3 and 4 of the Kidney Disease Outcome Quality Initiative. Chronic oral inflammatory burden was measured as 1) clinical periodontal infection categorized as no periodontal disease, periodontal disease (at least one tooth with ≥4 mm loss of attachment and bleeding on probing as an indicator of inflammation), or edentulism and 2) serum immunoglobulin G antibody response to Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) and Porphyromonas gingivalis. Multiple logistic regression modeling quantified the association between chronic kidney disease and chronic inflammatory burden and other risk factors. Results: Nine percent of the study population had chronic kidney disease, 22% had high A. actinomycetemcomitans antibody titer, 24% had high P. gingivalis antibody titer, 9% had periodontal disease, and 17% were edentulous. After simultaneously adjusting for recognized risk factors, adults with a high A. actinomycetemcomitans titer were less likely to have chronic kidney disease (adjusted odds ratio [OR<sub>Adj</sub>] = 0.67; 95% confidence interval [Cl]: 0.46 to 0.98), and adults with edentulism were more likely to have chronic kidney disease (OR<sub>Adj</sub> = 1.64; 95% CI: 1.11 to 2.44). Conclusion: These results support considering edentulism and low serum titer to A. actinomycetemcomitans as risk indicators for chronic kidney disease.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li><li>Ohio</li><li>État de New York</li></region><settlement><li>Buffalo (New York)</li><li>New York</li></settlement><orgName><li>Université Columbia</li><li>Université d'État de New York à Buffalo</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Scannapieco, Frank A" sort="Scannapieco, Frank A" uniqKey="Scannapieco F" first="Frank A." last="Scannapieco">Frank A. Scannapieco</name></region><name sortKey="Debanne, Sara M" sort="Debanne, Sara M" uniqKey="Debanne S" first="Sara M." last="Debanne">Sara M. Debanne</name><name sortKey="Fisher, Monica A" sort="Fisher, Monica A" uniqKey="Fisher M" first="Monica A." last="Fisher">Monica A. Fisher</name><name sortKey="Panesar, Mandip" sort="Panesar, Mandip" uniqKey="Panesar M" first="Mandip" last="Panesar">Mandip Panesar</name><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name><name sortKey="Rahman, Mahboob" sort="Rahman, Mahboob" uniqKey="Rahman M" first="Mahboob" last="Rahman">Mahboob Rahman</name><name sortKey="Taylor, George W" sort="Taylor, George W" uniqKey="Taylor G" first="George W." last="Taylor">George W. Taylor</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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